Lp(a): A Toolkit for Health Care Professionals

11 z In clinical practice, lifestyle modifications and statin therapy are commonly introduced together. The maximum percentage change will occur by four to 12 weeks after starting a statin or combined therapy. 14 z Review lifestyle habits such as diet, physical activity, weight or body mass index and tobacco use. Promote a healthy lifestyle and provide relevant advice, educational materials or referrals. 14 The AHA/ACC 2018 Guideline on the Management of Blood Cholesterol recommends assessing 10-year ASCVD risk and focusing on reducing LDL-C, primarily through the use of statin therapy. It advocates for more aggressive lowering of LDL-C on a percentage basis, (e.g., <50%). The AHA/ACC guidelines include a value statement regarding cost considerations for PCSK9 inhibitors. 22