12 Hypertension Guideline Toolkit for Healthcare Providers TREATMENT For the following comorbidities: • Diabetes mellitus • Chronic kidney disease • After renal transplantation • Heart failure • Stable ischemic heart disease • Peripheral artery disease BP Threshold ≥ 130/80 mm Hg BP Goal < 130/80 mm Hg For secondary stroke prevention BP Threshold ≥ 140/90 mm Hg BP Goal < 140/90 mm Hg Resistant Hypertension In clinical trials, resistant hypertension has developed in approximately 20% to 35% of patients with hypertension. It is important to address resistant hypertension because of an associated increased risk of cardiovascular events. The guideline defines treatment resistance and offers recommendations for evaluating and treating patients. Algorithm for Diagnosis, Evaluation and Treatment When setting BP thresholds and goals of pharmacologic therapy, you should consider your patients’ comorbidities. Treatment of Hypertension in Patients With Comorbidities The guideline also includes several recommendations for specific antihypertensive medications according to these comorbidities as well as others, such as acute intracerebral hemorrhage, atrial fibrillation, valvular heart disease and aortic disease.